Prothrombin Complex Concentrates

From Noblood

Prothrombin Complex Concentrates are a sterile, freeze-dried powder containing purified human clotting factors II, IX and X. It is prepared from blood collected from voluntary donors.

Contents 1 Primary component of origin 2 Percent of component 3 Production 4 Medicinal Value 5 Risks 6 Pharmaceuticals, found in 7 Alternatives 8 Factoids 9 See also

Primary component of origin

Plasma.

Percent of component

Production

The product is prepared from plasma. The solution is sterilised, freeze-dried and heated in the dry state to reduce the potential for viral transmission. Other ingredients are human plasma proteins 400 mg (which includes low levels of factors V and VII). May be suspended in a solution of plasma.

Medicinal Value

Used in the treatment of bleeding in patients with deficiency of factors IX, II or X and in patients with acquired prothrombin complex factor deficiency requiring partial or complete reversal (e.g. reversal of warfarin anti-coagulant therapy).[1]

Risks

Being a plasma product, prothrombin complex concentrates may transmit viruses or other infectious agents.[2]

Pharmaceuticals, found in

Proplex T, Koyne 80, Autoplex T, Prothrombinex.

Alternatives

Desmopressin, recombinant Factor VIIa.

Factoids

See also